@article{Jordão2024,

title = {Supercritical CO2-impregnation of clove extract in PLLA films: Assessing process parameter effects on extract loading and composition},

author = {Amanda Martins Jordão and João Henrique dos Anjos Cardoso and Eric Keven Silva and Lígia Passos Maia-Obi and Bruno Guzzo da Silva and Mathilde Champeau},

url = {https://www.sciencedirect.com/science/article/abs/pii/S089684462300308X},

doi = {10.1016/j.supflu.2023.106144},

issn = {0896-8446},

year  = {2024},

date = {2024-03-00},

urldate = {2024-03-00},

journal = {The Journal of Supercritical Fluids},

volume = {205},

publisher = {Elsevier BV},

abstract = {The supercritical carbon dioxide (scCO2) impregnation of clove extract (CE) into poly(L-lactic acid) (PLLA) films was explored with varying pressure (10–30 MPa) and temperature (35–60 °C), achieving high clove extract loadings (CL) (12.3 - 44.4%). In all conditions, impregnated extracts exhibited elevated eugenol content and reduced content of eugenyl acetate, β-caryophyllene, and α-humulene, compared to crude extract, showing the selective character of the process. Strong eugenol/PLLA affinity demonstrated by solubility parameters and hydrogen bonds permitted its effective impregnation. Eugenol significantly plasticized PLLA film, resulting in alterations in its microstructure, including increased crystallinity and smaller crystals. A CL of 23.8% maintained a dense and uniform structure of PLLA, while 44.4% induced a thick microporous layer on the surfaces. CE-impregnated PLLA, rich in eugenol, is promising for developing active food packaging and extract-releasing medical.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{daSilva2023h,

title = {PVC containing silver nanoparticles with antimicrobial properties effective against SARS-CoV-2},

author = {Daniel J. da Silva and Guilherme B. Gramcianinov and Pamela Z. Jorge and Vanessa B. Malaquias and Augusto A. Mori and Mário H. Hirata and Sergio A. M. Lopes and Luciano A. Bueno and Mathilde Champeau and Danilo J. Carastan},

url = {https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1083399/full},

doi = {10.3389/fchem.2023.1083399},

issn = {2296-2646},

year  = {2023},

date = {2023-03-13},

urldate = {2023-03-13},

journal = {Front. Chem.},

volume = {11},

publisher = {Frontiers Media SA},

abstract = {Poly (vinyl chloride) (PVC) is commonly used to manufacture biomedical devices and hospital components, but it does not present antimicrobial activity enough to prevent biofouling. With the emergence of new microorganisms and viruses, such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that was responsible for the global pandemic caused by Coronavirus Disease 2019 (COVID-19), it is evident the importance of the development of self-disinfectant PVC for hospital environments and medical clinics where infected people remain for a long time. In this contribution, PVC nanocomposites with silver nanoparticles (AgNPs) were prepared in the molten state. AgNPs are well-known as antimicrobial agents suitable for designing antimicrobial polymer nanocomposites. Adding 0.1 to 0.5 wt% AgNPs significantly reduced Young’s modulus and ultimate tensile strength of PVC due to the emergence of microstructural defects in the PVC/AgNP nanocomposites, but the impact strength did not change significantly. Furthermore, nanocomposites have a higher yellowness index (YI) and lower optical bandgap values than PVC. The PVC/AgNP nanocomposites present virucidal activity against SARS-CoV-2 (B.1.1.28 strain) within 48 h when the AgNP content is at least 0.3 wt%, suitable for manufacturing furniture and hospital equipment with self-disinfectant capacity to avoid secondary routes of COVID-19 contagion.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Jordão2022,

title = {Supercritical CO2 Impregnation of Clove Extract in Polycarbonate: Effects of Operational Conditions on the Loading and Composition},

author = {Amanda Martins Jordão and Isabela Trindade Coutinho and Eric Keven Silva and Ilka Tiemy Kato and Maria Angela A. Meireles and Lígia Passos Maia-Obi and Bruno Guzzo da Silva and Mathilde Champeau},

url = {https://www.mdpi.com/2227-9717/10/12/2661},

doi = {10.3390/pr10122661},

issn = {2227-9717},

year  = {2022},

date = {2022-12-00},

urldate = {2022-12-00},

journal = {Processes},

volume = {10},

number = {12},

publisher = {MDPI AG},

abstract = {The development of active packaging for food storage containers is possible through impregnation of natural extracts by supercritical CO2-assisted impregnation processes. The challenge of scCO2-impregnation of natural extracts is to control the total loading and to ensure that the composition of the loaded extract may preserve the properties of the crude extract. This study aimed at investigating the scCO2-impregnation of clove extract (CE) in polycarbonate (PC) to develop antibacterial packaging. A design of experiments was applied to evaluate the influences of temperature (35–60 °C) and pressure (10–30 MPa) on the clove loading (CL%) and on the composition of the loaded extract. The CL% ranged from 6.8 to 18.5%, and the highest CL% was reached at 60 °C and 10 MPa. The composition of the impregnated extract was dependent on the impregnation conditions, and it differed from the crude extract, being richer in eugenol (81.31–86.28% compared to 70.06 in the crude extract). Differential scanning calorimetry showed a high plasticizing effect of CE on PC, and high CL% led to the cracking of the PC surface. Due to the high loading of eugenol, which is responsible for the antibacterial properties of the CE, the impregnated PC is promising for producing antibacterial food containers.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Batista2022b,

title = {Advances in tissues and cells characterization by Raman micro‐spectroscopy, atomic force microscopy, and tip‐enhanced Raman spectroscopy},

author = {André M. Batista and Letícia Foiani and Mathilde Champeau and Herculano Martinho},

url = {https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jrs.6421},

doi = {10.1002/jrs.6421},

issn = {1097-4555},

year  = {2022},

date = {2022-11-00},

urldate = {2022-11-00},

journal = {J Raman Spectroscopy},

volume = {53},

number = {11},

pages = {1848--1860},

publisher = {Wiley},

abstract = {The comprehension of some diseases at the cellular and tissue scale is fundamental for the development of effective treatments for such conditions, and in this regard, Raman micro-spectoscopy, atomic force microscopy (AFM), and tip-enhanced Raman scattering (TERS) are techniques that have featured prominently in the characterization of biological materials like cells and tissues, since they allow the acquisition of detailed physical, chemical, biophysical, and physiological properties of the surface of these kind of samples such as elasticity, viscoelasticity, wettability, topography, molecular composition, and others. Due to this, this literature review has as its primary scope the presentation of some of the recent advances and new analysis methodologies using Raman, AFM, and TERS, pointing out what they can offer toward the investigation of the behavior of cells and biological tissues. Limits of usage, drawbacks, and future perspectives are presented and discussed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Dujarric2022,

title = {Solubility of aspirin, ketoprofen and R-(-)-carvone in supercritical CO2 in binary, ternary and quaternary systems: Effect of co-solutes},

author = {Katia Dujarric and Isabela Trindade Coutinho and Glaucia Toth Mantuaneli and Thierry Tassaing and Mathilde Champeau},

url = {https://www.sciencedirect.com/science/article/abs/pii/S0896844622001802},

doi = {10.1016/j.supflu.2022.105697},

issn = {0896-8446},

year  = {2022},

date = {2022-10-00},

urldate = {2022-10-00},

journal = {The Journal of Supercritical Fluids},

volume = {189},

publisher = {Elsevier BV},

abstract = {To better understand the solubility of multicomponent systems in supercritical CO2, an in situ IR spectrophotometer coupled to a high-pressure cell was used to measure the solubility of aspirin, ketoprofen and carvone in binary, ternary, and quaternary systems at 333.2 K and 353.2 K in pressures between of 5–30 MPa. DSC and ATR-FTIR allowed measuring the melting temperature of the compounds and optical microscopy was used to observe the phases. Aspirin formed a eutectic mixture with ketoprofen and was solubilized in carvone, resulting in an enhancement of its solubility in ternary and quaternary systems. On the contrary, ketoprofen solubility was higher in binary systems, due to a decrease in vapor pressure when in solution. Finally, carvone solubility was increased by the presence of other compounds at 333.2 K and pressures below 9 MPa, whereas at other conditions, the solubility decreased as a result of a decrease in vapor pressure.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Milani2022,

title = {Poly(acrylic acid)/polypyrrole interpenetrated network as electro‐responsive hydrogel for biomedical applications},

author = {Giorgio Marques Milani and Isabela Trindade Coutinho and Felipe Nogueira Ambrosio and Mônica Helena Monteiro do Nascimento and Christiane Bertachini Lombello and Everaldo Carlos Venancio and Mathilde Champeau},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/app.52091},

doi = {10.1002/app.52091},

issn = {1097-4628},

year  = {2022},

date = {2022-05-10},

urldate = {2022-05-10},

journal = {J of Applied Polymer Sci},

volume = {139},

number = {18},

publisher = {Wiley},

abstract = {The combination of conducting polymers and hydrogels in a conductive interpenetrated polymer network (CIPN) is an interesting strategy to mimic muscles and to create bending actuators. Whereas the conducting polymer ensures the electro pulse flux, the hydrogel provides structural support similar to human tissues. In this work, poly(acrylic acid) (PAA) and polypyrrole (PPy) CIPNs were synthesized in aqueous solution in three different compositions and characterized in terms of their morphology, composition, mechanical, and electrochemical properties, as well as cytotoxic and the bending behavior when submitted to an electric field. Fourier transform infrared spectroscopy indicated hydrogen interaction between PAA and PPy, and PPy doping level was not modified when polymerized inside the PAA structure. Mechanical properties and density were shown to increase with an increase in PPy content, whereas water content decreased. Surprisingly, PAA/PPy CINPs presented some toxicity that may be due to the sterilization technique. Finally, PAA/PPy CIPNs responded mechanically to electrical stimuli and good curve symmetry and reversibility were observed in the cyclic voltammogram tests. These results indicate that the CIPN containing a PAA/PPy ratio of 1:0.3 is promising to prepare biocompatible soft bending actuators such as artificial muscles.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Coutinho2021,

title = {Aspirin-Loaded Polymeric Films for Drug Delivery Systems: Comparison between Soaking and Supercritical CO2 Impregnation},

author = {Isabela Trindade Coutinho and Lígia Passos Maia-Obi and Mathilde Champeau},

url = {https://www.mdpi.com/1999-4923/13/6/824},

doi = {10.3390/pharmaceutics13060824},

issn = {1999-4923},

year  = {2021},

date = {2021-06-00},

urldate = {2021-06-00},

journal = {Pharmaceutics},

volume = {13},

number = {6},

publisher = {MDPI AG},

abstract = {Polymeric implants loaded with drugs can overcome the disadvantages of oral or injection drug administration and deliver the drug locally. Several methods can load drugs into polymers. Herein, soaking and supercritical CO2 (scCO2) impregnation methods were employed to load aspirin into poly(l-lactic acid) (PLLA) and linear low-density polyethylene (LLDPE). Higher drug loadings (DL) were achieved with scCO2 impregnation compared to soaking and in a shorter time (3.4 ± 0.8 vs. 1.3 ± 0.4% for PLLA; and 0.4 ± 0.5 vs. 0.6 ± 0.5% for LLDPE), due to the higher swelling capacity of CO2. The higher affinity of aspirin explained the higher DL in PLLA than in LLDPE. Residual solvent was detected in LLDPE prepared by soaking, but within the FDA concentration limits. The solvents used in both methods acted as plasticizers and increased PLLA crystallinity. PLLA impregnated with aspirin exhibited faster hydrolysis in vitro due to the catalytic effect of aspirin. Finally, PLLA impregnated by soaking showed a burst release because of aspirin crystals on the PLLA surface, and released 100% of aspirin within 60 days, whereas the PLLA prepared with scCO2 released 60% after 74 days by diffusion and PLLA erosion. Hence, the scCO2 impregnation method is adequate for higher aspirin loadings and prolonged drug release.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lima2021,

title = {Boron nitride-based nanocomposite hydrogels: preparation, properties and applications},

author = {Diego Moreira Lima and Anne Cristine Chinellato and Mathilde Champeau},

url = {https://pubs.rsc.org/en/content/articlelanding/2021/sm/d1sm00212k/unauth},

doi = {10.1039/d1sm00212k},

issn = {1744-6848},

year  = {2021},

date = {2021-05-05},

urldate = {2021-05-05},

journal = {Soft Matter},

volume = {17},

number = {17},

pages = {4475--4488},

publisher = {Royal Society of Chemistry (RSC)},

abstract = {Hexagonal boron nitride (h-BN) nanostructures are well-known for their good chemical stability, thermal conductivity and high elastic modulus. BN can be used as a filler in hydrogels to significantly improve their mechanical and thermal properties, to reinforce their biocompatibility and to provide self-healing capacity. Moreover, in contrast with their carbon equivalents, BN nanocomposites are transparent and electrically insulating. Herein, we present an overview of BN-based nanocomposite hydrogels. First, the properties of h-BN are described, as well as common exfoliation and functionalization techniques employed to obtain BN nanosheets. Then, methods for preparing BN-nanocomposite hydrogels are explained, followed by a specific overview of the relationship between the composition and structure of the nanocomposites and the functional properties. Finally, the main properties of these materials are discussed in view of the thermal, mechanical, and self-healing properties, along with the potential applications in tissue engineering, thermal management, drug delivery and water treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}